IGF-1 LR3 (Long R3) Research Overview
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a synthetic analogue of human IGF-1. It is modified with an extra 13 amino acids at the N-terminus and a substitution of Glutamine for Arginine at position 3, making it significantly more potent than standard IGF-1 by preventing binding to inhibitory proteins and extending its half-life.
Mechanism of Action
IGF-1 LR3 functions as a highly potent mediator of growth hormone effects:
- Binding Protein Evasion The LR3 modification prevents the peptide from being deactivated by IGF-binding proteins (IGFBPs), allowing more of the compound to remain active in the system.
- Hyperplasia Induction Uniquely studied for its potential to stimulate the division and proliferation of new muscle cells (hyperplasia), rather than just enlarging existing ones.
- Glucose Transport Enhances the transport of glucose and amino acids into muscle cells, supporting cellular energy and growth.
- Extended Half-Life Exhibits a significantly longer duration of action (20–30 hours) compared to standard IGF-1, making it a more stable subject for research.
Research Benefits & Applications
In preclinical and laboratory research, IGF-1 LR3 is studied for the following potential effects:
- Muscle Tissue Development Investigated for its role in muscle hypertrophy and the creation of new muscle fibers.
- Enhanced Recovery Studied for its ability to accelerate the repair of connective tissues, ligaments, and muscle fibers after injury.
- Fat Metabolism May promote the use of fat for energy while preserving lean tissue in various research models.
- Cellular Longevity Explored for its neuroprotective properties and role in overall cellular regeneration.
Potential Risks & Side Effects
Researchers should monitor for the following considerations:
- Hypoglycemia (low blood sugar) due to its insulin-like properties
- Joint pain or swelling in certain research models
- Potential for organ growth if systemic levels are not strictly controlled
- Headaches or lethargy during the initial research phases
Product Specifications
| Feature | Specification |
|---|---|
| Form | Lyophilized (Freeze-Dried) Powder |
| Molecular Weight | ~9111 Da |
| Purity | >99% (HPLC Verified) |
| Storage | Store in a cool, dry place; refrigerate at 2°C–8°C after reconstitution |
Safety Precautions & Compliance
⚠️ FOR RESEARCH USE ONLYThis compound is provided exclusively for laboratory research purposes. It is strictly prohibited for human or animal consumption, medical use, or therapeutic application.
- Reconstitution Typically requires an acetic acid solution or sterile water. Do not shake the vial as the peptide is highly sensitive.
- Handling Must be handled only by qualified researchers in controlled laboratory environments.
- Legal Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
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