GHK-Cu (Copper Peptide) Research Overview
GHK-Cu is a naturally occurring tripeptide (glycyl-L-histidyl-L-lysine) that binds copper ions. It is found in human plasma, saliva, and urine, but levels decrease with age. It is a key research compound for gene expression modulation, tissue repair, and maintaining skin, hair, and bone health.
Mechanism of Action
GHK-Cu functions through several biological pathways to promote regeneration:
- Collagen and Elastin Synthesis Stimulates fibroblasts to produce critical extracellular matrix proteins, improving skin elasticity and structure.
- Angiogenesis Facilitates the formation of new blood vessels and tissue oxygenation during wound healing.
- Anti-Inflammatory and Antioxidant Effects Reduces cytokine activity (IL-6, TNF-alpha), blocks oxidative stress, and mitigates ROS damage.
- Matrix Remodeling Regulates metalloproteinases to remove damaged tissue while promoting new tissue formation.
- Hair Follicle Stimulation Enhances hair growth by prolonging the anagen phase and supporting dermal papilla cells.
Research Benefits & Applications
In preclinical and laboratory research, GHK-Cu is studied for the following potential effects:
- Skin and Anti-Aging Increases skin firmness and density while reducing fine lines and wrinkles.
- Wound Healing Enhances wound contraction and epithelialization, particularly in chronic or diabetic wound models.
- Hair Growth Improves scalp circulation and hair thickness, with reported efficacy comparable to 5% Minoxidil.
- Neuroprotection Enhances nervous system regeneration through axonal growth and Schwann cell proliferation.
- Lung and Cardiovascular Health Supports lung fibroblast function and healthy cardiovascular tissue.
Potential Risks & Side Effects
Researchers should monitor for the following considerations:
- Skin irritation or redness if applied topically in concentrated research forms
- Potential for copper toxicity if systemic levels are not monitored in research models
- Limited human data for long-term high-dose applications
- Sensitivity to the blue-pigmented solution during handling
Product Specifications
| Feature | Specification |
|---|---|
| Form | Lyophilized (Freeze-Dried) Powder |
| Color | Distinct Blue (Natural Copper Complex) |
| Purity | >99% (HPLC Verified) |
| Storage | Store in a cool, dry place; refrigerate at 2°C–8°C after reconstitution |
Safety Precautions & Compliance
⚠️ FOR RESEARCH USE ONLYThis compound is provided exclusively for laboratory research purposes. It is strictly prohibited for human or animal consumption, medical use, or therapeutic application.
- Reconstitution Typically reconstituted with sterile water. Ensure the solution remains a clear blue.
- Handling Must be handled only by qualified researchers in controlled environments.
- Legal Notice This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure, or prevent any disease.
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